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Jumat, 31 Juli 2009

Aquaman


Aquaman is a comic figure that originally appeared in DC Comics series. Young people before the Generation Y may be known. Kisahnya, there is a champion of the kingdom of Atlantis delusion, operate in the sea. Like Superman is Clark Kent and Bruce Wayne is Batman, Aquaman is Arthur Curry. Aquaman has strength that is unique to breathe in the sea. Moreover he can communicate with sea animals and even the sentient sea waves through the mind. Of course, she can swim very fast and very long. He high-pressure resistance in the depth of the sea and the sea is like. But in the land he indifferently, kantoran people like you and me.

aquaman.jpg



So? We may also have a few attributes Aquaman, but in general we landlubber. Even first-used to live in a tree. In the land-we are just ordinary, looking for work and living socially, the way to the mall, vacation to the mountain. Untung-fortunately swim to the sea, but only up to one meter depth.

If I can share a few personal stories, my life in the land, the foot was quite so weak and difficult road. Not sick, but rather that totter and fall can be encouraged. Continue if established after a long time and if so pegel road so far tired. Body part other than just look good foot, and walk of life continue, even eager to know why lately. So no problem foot problem, many compensation.

Consolation is that with the lower legs, so to even strong swimmers. No pool can be a champion, but most can not swim long and quiet. With the glasses (goggle) we can see in the water and watch the people passing. All float in Suspensi, including time. The world does not revolve as semjua and teredam voice, very quiet.

Most important, the water in the weak leg work the same as other people., The lean, fat people in the same water. We know teri fish and whales alike can swim, and they do not need feet. Yes, the main deh world's water is suitable for people who are difficult to walk.

Aquaman ever appeared in the film and get new friends as Aqualad, but he was less successful than seprofesi colleagues. Superman, Batman is much more powerful (perhaps because the mainstream) and the recent Spiderman melejit forward as new stars form the day-to-day exactly the Ordinary People. Aquaman even dicemoohkan that kehebatannya is limited. What's the superhero so if pursuing criminals? Live up to the land, pass directly to the criminals be pursued Aquaman.

But that does not pursue criminals, life in the water can be enjoyed enough to compensate for the limitations of life on land difficult for people on foot. Evidence that the limitations apply only to a certain environment, and can be solved if we change the environment. People who feel can not talk, will be regarded critic if he moved smoothly to the culture of silence. People that are less preferred because in many less smile, can move to Russia where the people can not smile unless there are special issues with a known good. Secret to be able to function well is the introduction of the environment.

There are still people like that dimarahin. In Western environment, be considered dangerous for that he menggodok revenge scenario while membungbkam thousand languages. In this culture, if people continue to replicate dimarahi time, even considered challenging. In high school, have teachers who love to get mad if there are students who hold a time be reproved. Finally, the teacher cried out: "Why do you say continue? You think I fear in you?"

"No, Sir." Responsibility of the students. "I just want to give feedback." Wah the child is considered downright gauche, even by their own friends. "Ngapain you here? How to learn or want to play ball? Tuh, outside the main ball. Take it like that." Show your face again and Pak Guru seisi class, the children, without expression, go out and play ball have participated.

He should go to the swimming pool and become Aquaman, may be more peaceful for him, free from pressure.


By : Lupus

BatGirl


Batgirl is the name of several fictional characters appearing in comic books published by DC Comics, depicted as female counterparts to the superhero Batman. Originally created by Bob Kane and Sheldon Moldoff, the first incarnation of the character, the "Bat-Girl" Betty Kane, debuted in Batman #139 (1961). Following the promotion of Julius Schwartz to editor of the Batman-related comic book titles in 1964, the Bat-Girl character was removed from publication and replaced by the "new" Batgirl Barbara Gordon in 1967. The new character was introduced in Gardner Fox and Carmine Infantino's Detective Comics #359, entitled "The Million Dollar Debut of Batgirl".

The Barbara Gordon version of Batgirl made regular appearances in Batman-related comics from 1966 to 1988. The official retirement of Batgirl took place in Batgirl Special #1 (June 1988), which was published a few months after Barbara Gordon's shooting by The Joker in the graphic novel Batman: The Killing Joke (March 1988). Editor Kim Yale and comic book author John Ostrander later reinvented Barbara Gordon as Oracle, the premier information broker of the DC Comics Universe and leader of the Birds of Prey organization.

In the 1999 story Batman: No Man's Land, Helena Bertinelli briefly assumes the role of Batgirl, until she is stripped of the identity by Batman towards the conclusion of the story for violating his stringent codes. Within the same year, a new character introduced during the No Man's Land series, named Cassandra Cain, created by Kelley Puckett and Damion Scott, becomes the third Batgirl, and she is mentored by Batman and Oracle. Cassandra Cain was the first version of the Batgirl character to be featured in an eponymous monthly series, which was canceled in 2006, ending with Cain relinquishing her title as Batgirl. During the "Headhunt" arc of the Birds of Prey comic book series, the Charlotte Gage-Radcliffe character created by Gail Simone temporarily took the name of Batgirl, but was eventually forced to abandon the role by Oracle and subsequently adopted the alias "Misfit." Following the events of the limited series 52 (2006), the Cassandra Cain character reclaimed her former identity as Batgirl.

DC has announced a new "Batgirl" comic series will begin August 2009, but the company has not specified which version of the character will star.

St John's Wort - The Perfect Antidepressant, If You're German

The herb St John's Wort is as effective as antidepressants while having milder side effects, according to a recent Cochrane review, St John's wort for major depression.

Professor Edzard Ernst, a well-known enemy of complementary and alternative medicine, wrote a favorable review of this study in which he comments that given the questions around the safety and effectiveness of antidepressants, it is a mystery why St John's Wort is not used more widely.

When Edzard Ernst says a herb works, you should take notice. But is St John's Wort (Hypericum perforatum) really the perfect antidepressant? Curiously, it seems to depend whether you're German or not.

The Cochrane review included 29 randomized, double-blind trials with a total of 5500 patients. The authors only included trials where all patients met DSM-IV or ICD-10 criteria for "major depression". 18 trials compared St John's Wort extract to placebo pills, and 19 compared it conventional antidepressants. (Some trials did both).

The analysis concluded that overall, St John's Wort was significantly more effective than placebo. The magnitude of the benefit was similar to that seen with conventional antidepressants in other trials (around 3 HAMD points). However, this was only true when studies from German-speaking countries were examined.

Out of the 11 Germanic trials, 8 found that St John's Wort was significantly better than placebo and the other 3 were all very close. None of the 8 non-Germanic trials found it to be effective and only one was close.


Edzard Ernst, by the way, is German. So were the authors of this review. I'm not.

The picture was a bit more clear when St John's Wort was directly compared to conventional antidepressants: it was almost exactly as effective. It was only significantly worse in one small study. This was true in both Germanic and non-Germanic studies, and was true when either older tricyclics or newer SSRIs were considered.

Perhaps the most convincing result was that St John's Wort was well tolerated. Patients did not drop out of the trials because of side-effects any more often than when they were taking placebo (OR=0.92), and were much less likely to drop out versus patients given antidepressants (OR=0.41). Reported side effects were also very few. (It can be dangerous when combined with certain antidepressants and other medications however.)

So, what does this mean? If you look at it optimistically, it's wonderful news. St John's Wort, a natural plant product, is as good as any antidepressant against depression, and has much fewer side effects, maybe no side effects at all. It should be the first-line treatment for depression, especially because it's cheap (no patents).

But from another perspective this review raises more questions than answers. Why did St John's Wort perform so differently in German vs. non-German studies? The authors admit that:
Our finding that studies from German-speaking countries yielded more favourable results than trials performed elsewhere is difficult to interpret. ... However, the consistency and extent of the observed association suggest that there are important differences in trials performed in different countries.
The obvious, cynical explanation is that there are lots of German trials finding that St John's Wort didn't work, but they haven't been published because St John's Wort is very popular in German-speaking countries and people don't want to hear bad news about it. The authors downplay the possibility of such publication bias:
We cannot rule out, but doubt, that selective publication of overoptimistic results in small trials strongly influences our findings.
But we really have no way of knowing.

The more interesting explanation is that St John's Wort really does work better in German trials because German investigators tend to recruit the kind of patients who respond well to St John's Wort. The present review found that trials including patients with "more severe" depression found slightly less benefit of St John's Wort vs placebo, which is the opposite of what is usually seen in antidepressant trials, where severity correlates with response. The authors also note that it's been suggested that so-called "atypical depression" symptoms - like eating too much, sleeping a lot, and anxiety - respond especially well to St John's Wort.

So it could be that for some patients St John's Wort works well, but until studies examine this in detail, we won't know. One thing, however, is certain - the evidence in favor of Hypericum is strong enough to warrant more scientific interest than it currently gets. In most English-speaking psychopharmacology circles, it's regarded as a flaky curiosity.

The case of St John's Wort also highlights the weaknesses of our current diagnostic systems for depression. According to DSM-IV someone who feels miserable, cries a lot and comfort-eats icecream has the same disorder - "major depression" - as someone who is unable to eat or sleep with severe melancholic symptoms. The concept is so broad as to encompass a huge range of problems, and doctors in different cultures may apply the word "depression" very differently.

[BPSDB]

ResearchBlogging.orgErnst, E. (2009). Review: St John's wort superior to placebo and similar to antidepressants for major depression but with fewer side effects Evidence-Based Mental Health, 12 (3), 78-78 DOI: 10.1136/ebmh.12.3.78

Klaus Linde, Michael M Berner, Levente Kriston (2008). St John's wort for major depression Cochrane Database of Systematic Reviews (4)

Rabu, 29 Juli 2009

Bigmouth Strikes Again

In the Guardian, Oliver James gets his hands on some mental health statistics. As I have explained before, this rarely ends well. Zarathustra of the really wonderful Mental Nurse blog takes James to to task. Hilarity ensues.

[BPSDB]

Minggu, 26 Juli 2009

Tracing The Roots of Anime

From the popular Transformers movie release to the Yu-Gi-Oh! cards your kids might have, anime has certainly left its mark on the world in recent years. Understanding its roots, though, is the key to predicting where this ever-changing genre is headed.

Before you can understand the history of anime, maybe it's first necessary to understand exactly what anime is. "Anime" literally means animation in Japanese. It does not distinguish one style from another; it's simply a way to talk about animation of all types.

Worldwide, though, anime is what we call a particular style of Japanese art and animation. Because of its popularity in recent years, the term ‘anime' has come to mean a style rather than animation that comes specifically from Japan. Through the years, anime has also been known by other names. Japanime is one, and Japanimation is another. Manga is a more recent, and perhaps controversial, term for anime-style comic books.

A Bit of History

While lots of animation was produced in Japan from about 1917 on, the anime that we know and love today is considered to have been created by Tezuka Osamu, who started drawing comic books in 1947. His character Astroboy (or Tetsuwan Atomu as he is known in Japan) hit television screens around Japan in 1963, which is generally considered to be the first mainstream anime cartoon. What's more is that Tezuka Osamu helped to create the giant robot genre that has been such an ongoing theme in both anime and manga.

Anime became such a popular art form in Japan because the live action film genre was simply too expensive to be a hit. As a result, some of the same thematic steps western filmmakers were taking in the world of live action were being taken in Japanese animation simultaneously.

The Real Difference

As a whole, anime is quite different from American animation. Anime encompasses complex story lines of nearly every genre as well as thought-provoking characters that most American animation stays away from. Since American animation is considered "kid's stuff," and anime is a mainstream form of entertainment for all kinds of people in Japan, lots of people misinterpret anime's intentions.

While some of anime is okay for you and your children to view together, many films contain adult themes and situations that aren't okay for younger viewers. Keep in mind that Japan has very different attitudes about nudity, strong language, and violence, so plopping your toddler down in front of anime because it's a cartoon just isn't a good idea.

Like the Idea?

If you're interested in exploring anime further, there are several films that are considered to be classics to the genre as a whole. Try starting with Princess Mononoke. With a strong plot and beautiful style, you're sure to fall in love with this type of animation instantly.

Inuyasha - Son of a Demon Dog


INUYASHA

DEEP THROW THE WISHING WELL

WHAT?

KNEEL DEMON DOG

DID SESSHOUMARU’S ARM EVER GROW BACK?

SWIM FOR IT

A HERO’S JOURNEY

TALL TALES

INUYASHA

Here’s the lowdown, “Inuyasha” is the story of a 15 year old schoolgirl named Kagome Higurashi who lives at a Japanese shrine. She just happens to be the reincarnation of an ancient priestess named Kikyo. Kikyo guarded the sacred Shikon no Tama, also known as the ‘Jewel of Four Souls’. Long ago Kikyo captured and sealed away a half-demon named Inuyasha who was attempting to steal the jewel in order to become a full-fledged demon. Kikyo ultimately died and had the jewel burned with her body.

DEEP THROW THE WISHING WELL

One day, Kagome was pulled into an ancient well and plunged deep into the past, 50 years after Kikyo’s death. This is the world feudal era Japan in the 1500’s and there she meets up with Kaede, Kikyo’s sister. Kaede realizes Kagome is Kikyo’s reincarnation and together they find out that the sacred jewel is hidden inside Kagome’s body. By accident the jewel is ripped from her body and the dog-demon, Inuyasha is released. He of course, immediately wants the jewel for himself. To thwart his attempts, Kaede casts a spell on him where he must wear a necklace that allows Kaede to control his actions with one simple word, “Sit!”. If you’re not interested in the story at this point, you’re just not getting it. This is cool stuff.

WHAT?

Inuyasha is pronounced, (ee-new-yah-sha)

KNEEL DEMON DOG

When Kagome says the magic word it forces Inuyasha face first into the ground. The precious jewel accidently gets shattered while they try to retrieve it from a giant bird who stole it. And together, Kaede and Inuyasha must find all the shards and put it back together before it falls into the wrong hands. Theirs is a match made in heaven and they must learn to get along in order to survive. A new twist on a ‘girl and her demon dog’.

DID SESSHOUMARU’S ARM EVER GROW BACK?

You know a show has to be good if a fan has to ask if one of the characters’ left arm ever grew back after the lead character hacked it off before transforming into a giant furry white dog.

SWIM FOR IT

Luckily for American fans, the good people at the Cartoon Network regularly added ‘Inuyasha’ to the Adult Swim line up. After seeing the Japanese version as well, the English dubbed version and the voice talent really help fill out the world. If you liked the Japanese animated films, ‘Spirited Away’ or ‘Princess Mononoke’ or live action fare like, ‘Buffy the Vampire Slayer’, ‘Angel’ or ‘Crouching Tiger Hidden Dragon’, then you definitely should give ‘Inuyasha’ a whirl.

A HERO’S JOURNEY

Asides from the inventive mythological influenced set up, the ‘Inuyasha’ series and films are just really well told stories. The half hour episodes truly pack it in and give you dynamic and rich story is a compact time frame.

TALL TALES

Just to keep you guys up with the ‘Inuyasha’ universe, there have been three feature length films released, “Inuyasha: Love that Transcends Time”, “Inuyasha: The Castle Beyond the Looking Glass” and most recently – “Inuyasha: Sword to Rule the World”.

Sabtu, 25 Juli 2009

In Science, Popularity Means Inaccuracy

Who's more likely to start digging prematurely: one guy with a metal-detector looking for an old nail, or a field full of people with metal-detectors searching for buried treasure?

In any area of science, there will be some things which are more popular than others - maybe a certain gene, a protein, or a part of the brain. It's only natural and proper that some things get of lot of attention if they seem to be scientifically important. But Thomas Pfeiffer and Robert Hoffmann warn in a PLoS One paper that popularity can lead to inaccuracy - Large-Scale Assessment of the Effect of Popularity on the Reliability of Research.

They note two reasons for this. Firstly, popular topics tend to attract interest and money. This means that scientists have much to gain by publishing "positive results" as this allows them to get in on the action -
In highly competitive fields there might be stronger incentives to “manufacture” positive results by, for example, modifying data or statistical tests until formal statistical significance is obtained. This leads to inflated error rates for individual findings... We refer to this mechanism as “inflated error effect”.
Secondly, in fields where there is a lot of research being done, the chance that someone will, just by chance, come up with a positive finding increases -
The second effect results from multiple independent testing of the same hypotheses by competing research groups. The more often a hypothesis is tested, the more likely a positive result is obtained and published even if the hypothesis is false. ... We refer to this mechanism as “multiple testing effect”.
But does this happen in real life? The authors say yes, based on a review of research into protein-protein interactions in yeast. (Happily, you don't need to be a yeast expert to follow the argument.)

There are two ways of trying to find out whether two proteins interact with each other inside cells. You could do a small-scale experiment specifically looking for one particular interaction: say, Protein B with Protein X. Or you can do "high-throughput" screening of lots of proteins to see which ones interact: Does Protein A interact with B, C, D, E... Does Protein B interact with A, C, D, E... etc.

There have been tens of thousands of small-scale experiments into yeast proteins, and more recently, a few high-throughput studies. The authors looked at the small-scale studies and found that the more popular a certain protein was, the less likely it was that reported interactions involving it would be confirmed by high-throughput experiments.

The second and the third of the above graphs shows the effect. Increasing popularity leads to a falling % of confirmed results. The first graph shows that interactions which were replicated by lots of small-scale experiments tended to be confirmed, which is what you'd expect.

Pfeiffer and Hoffmann note that high-throughput studies have issues of their own, so using them as a yardstick to judge the truth of other results is a little problematic. However, they say that the overall trend remains valid.

This is an interesting paper which provides some welcome empirical support to the theoretical argument that popularity could lead to unreliability. Unfortunately, the problem is by no means confined to yeast. Any area of science in which researchers engage in a search for publishable "positive results" is vulnerable to the dangers of publication bias, data cherry-picking, and so forth. Even obscure topics are vulnerable but when researchers are falling over themselves to jump on the latest scientific bandwagon, the problems multiply exponentially.

A recent example may be the "depression gene", 5HTTLPR. Since a landmark paper in 2003 linked it to clinical depression, there has been an explosion of research into this genetic variant. Literally hundreds of papers appeared - it is by far the most studied gene in psychiatric genetics. But a lot of this research came from scientists with little experience or interest in genes. It's easy and cheap to collect a DNA sample and genotype it. People started routinely looking at 5HTTLPR whenever they did any research on depression - or anything related.

But wait - a recent meta-analysis reported that the gene is not in fact linked to depression at all. If that's true (it could well be), how did so many hundreds of papers appear which did find an effect? Pfeiffer and Hoffmann's paper provides a convincing explanation.

Link - Orac also blogged this paper and put a characteristic CAM angle on it.

ResearchBlogging.orgPfeiffer, T., & Hoffmann, R. (2009). Large-Scale Assessment of the Effect of Popularity on the Reliability of Research PLoS ONE, 4 (6) DOI: 10.1371/journal.pone.0005996

Jumat, 24 Juli 2009

Everyone is Mentally Ill

There's been a lot of interest over the idea that an "Artificial brain is 10 years away", which is what Professor Henry Markram told the ultra-hip TED conference in Oxford the other day.

That's an amazing idea. But Markram said something else even more astonishing, which, for some reason, has not got nearly as much attention:
"There are two billion people on the planet affected by mental disorder," he told the audience.
Two billion people. One in three.

This was presumably a throw-away remark, something he said in order to emphasise the importance of understanding the brain. But this makes it even more amazing: we have reached the point where no-one bats an eyelid at the idea that mental illness affects one in three people worldwide.

Well, if this is what we believe now, I think we need to stop beating about the bush with numbers like one in four or one in three, and admit that we now are now using "mental illness" as a synonym for "the human condition".

After all, once you pass the point where one in two people have something, you are saying that it's normal and not having it is weird. As I've written before, if you take the evidence seriously, more than 50% of people are indeed "mentally" ill at some point. So let's just say that everyone is mentally ill and have done with it.

Or we could reassess what we mean by "mental illness" and stop medicalizing human suffering. Hey, we can dream.

Kamis, 23 Juli 2009

SpongeBob SquarePants


SpongeBob SquarePants is an animated series the most popular on Nickelodeon. Initially, this cartoon series shown in 1999 in the United States and created by Stephen Hillenburg, an animator and marin biologist, and he diterbit by syarikat, United plankton Pictures Inc. This series of cartoons showing in Malaysia menerusi channel TV3 and Nickelodeon, and also through the channel TV9 to dialihbahasa was in Malay.

In this series dipopulerkan by LaTiVi (now TvOne), and the right to run events that are produced by Nickelodeon bought by Global TV. This cartoon was created by a marine biologist and animator Stephen Hillenburg and then released through the company plankton United Pictures Inc. This serial settings are in the Pacific Ocean in the city of "Bikini Bottom".

SpongeBob SquarePants is a spons who lives in a pineapple in the sea in the city of Bikini Bottom, Squidward Tentacles, when tetanggannya octopus is an animal that lives in the home moai. Neighbors SpongeBob and the other akrabnya friend, Patrick Star a pink sea stars, live under a rock. Squidward's house is located between the home Spongebob and Patrick's house, and this is the meresahkan Squidward.

SpongeBob and his friends live in the city of Bikini Bottom in the Pacific ocean. Bikini Bottom dilihatkan as a normal city with the city center, edge of town, the beach area, airport, sea and flower arrangements on your own amusement park. Stephen Hillenburg said once that Bikini Bottom-up more or less based on the city of Seattle, Washington.

Pets SpongeBob is a sea snail called Gary, who "mengiau" like a cat. Although many do not speak (except in a few episodes), fiber-fiber is able to understand another look. Moreover, sea worms and bark like a dog dirantai. Jellyfish equated with the bees, the sound of whispering, sengatan can (but look like electric shocks), and the "jelly" delicious, make fun of the name "jellyfish", while the jelly with honey bees. Fish role as citizens of the city but not as important character.

SpongeBob is penyerap, yellow, and these holes, working as a chef at the Krusty Krab, a fast food restaurant food, where Squidward also worked as a cashier. Krusty Krab is owned Eugene H. Krabs (Mr. Krabs). Sheldon J. Plankton bebuyutan Krabs is the enemy that has a fast food restaurant food low stages chum called The Bucket located opposite the Krusty Krab. The chum Bucket apparently never visited by customers, and plankton to spend most of the time to design the equipment to steal Krabby Patty burger recipe property Mr. Krabs. Plankton only successfully steal the recipe in The Spongebob Squarepants Movie; formula was never shown to the audience. Plankton computer wife, Karen, once in a while helping in the design or jahatnya contend with.

One of SpongeBob is Sandy Cheeks, a squirrel who comes from Texas and live in the anti-air turret in Bikini Bottom. He was transported to the sea by employers-employers in the form of chimpanzee. When outside kubahnya, he was wearing clothes like astronauts.

Population Bikini Bottom drive boats as though the car. SpongeBob is still studying in school after failing the driving test driving hundreds of times. Every movement of the bubbles to mengingkatkan audience that this story berlatarkan sea. However, there is a phase-phase in which there is a separate selapisan water from sea water (such as Tasik beach) and start a fire in the sea water.

Avatar: The Legend of Aang


Avatar, the last wind controllers; known as Avatar: The Last Airbender in the United States and some countries) is an animated television series shown by the United States television network Nickelodeon. Taking place in the world of martial arts and magic elements of nature with the influence of Asia, following the adventure story for the sake of the adventure of a degree called Avatar Aang and his friends on their way to save the world from the State Fire impure. Serial written this book in serial form, with each episodenya considered as a "chapter" (chapter), and each season is called the "book" (book). In Indonesia, the film is displayed by Global TV.

Avatar: The Legend of Aang take place in a fantasy world, where people live, fantastik various animals, and spirits. Human civilization divided into the four-nation, The Water (Water Tribe), Kingdom of Earth (Earth Kingdom), nomadic Air (Air Nomads), and the State Fire (Fire Nation). In every nation there are those who are called Bender (literally means "Pembengkok", but in this case is "Control") that has the ability to control elements of nature according to their nations. Control the natural elements of art is a fusion style of martial arts and magic elements of nature.

In each generation, there is someone who is able to control every element, which is called as the Avatar, the spirit of the planet incarnate in human form. When an Avatar dies, he will be born again in a nation that always turn alternately in accordance with the cycle Avatar, which along with the seasons: winter for water, spring for earth, summer for fire, and autumn for air. Legend says that the Avatar must learn the art elements according to the order, starting with the elements of the original peoples of the Avatar, but sometimes this can dilewat order if circumstances force. Learn the elements of control contrary to the original elements of a nation is very difficult because of differences in style of martial arts and its doctrines.

Seabad before the opening of the story of this series, Aang, a boy aged wind controllers 12 years of Air Temple Southern Air owned by the nomadic, was told by the elders that he is "the Avatar". Typically, a teak Avatar told himself as an Avatar go when he was 16 years old, however, the biksu fear that war will occur between the four nations will soon take place and in a short time Questioner akan needed to maintain balance and peace of the world. This makes Aang is confusion and depression. Short stories, fading Aang's Southern Air Temple, but in the middle of the road he met with a very large storm, and he along with Appa (a giant flying bison own) fall in the sink to the sea. But Aang immediately make the air around the ball body and Appa that he does not wet. Freeze the ball in the air in the surrounding water so that Aang and Appa in bongkahan imprisoned in ice.

In episode "The Boy in the Iceberg," two teenagers from the Southern Water Tribe named Katara - a water control - and a brother named Sokka, Aang finds a bongkahan in ice, and then they membebaskannya. Then the explanation of them, know that during Aang he disappears, the fear of a monk akan war has become a reality. For many years he was vague during, which the State Fire control the house fire, to demolish the other three nations, namely the Kingdom of Earth, The Water, Air and nomadic. All the air temples destroyed, including the nomadic Air, be all that can not bereinkarnasi Avatar. This is causing Aang to be the last air controllers in the face of the earth. It is the duty to learn the four elements, in order to overcome the fires of King and bring back peace and harmony on earth. To run a task, accompanied by the Aang Katara and Sokka, along with two animal peliharaannya - Momo and Appa - to seek expert control elements and learning to become an Avatar, and at the same time they must avoid catching the efforts by the State Fire .

Major Huntington's Disease Puzzle Solved

Huntington's Disease is a genetic neurological disorder. Symptoms most commonly appear around age 40, and they progress gradually from subtle movement abnormalities to complete loss of motor control and dementia. Psychiatric problems, especially depression and irritability, are also common and may be the first signs. Treatment consists of medications to mask some of the symptoms. Singer Woodie Guthrie is perhaps the disease's best known victim: he ended his days in a mental institution.

Huntington's results from mutations in the gene which makes a protein called Huntingtin (Htt). The symptoms are associated with degeneration of various parts of the brain, most importantly, a deep region called the striatum. These facts have been known for many years, but it's unclear how mutant Htt damages the brain. There are various theories, but they've all faced a serious puzzle - Htt is expressed in all adult human cells, but Huntington's only affects some neurones. Why?

A major new paper claims to have the answer : Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity. It also suggests a promising target for drugs that could prevent the damage from occuring.

The authors assemble evidence showing that mutant Htt kills cells only in conjunction with another protein called Rhes. Crucially, Rhes is only expressed in striatal cells. They found that:
  • Rhes binds to Htt, but it binds much more strongly to mutant Htt.
  • Causing cells to express both Rhes and mutant Htt leads to cell death, but either by its own does not.
  • Rhes mediates the binding of mutant Htt to another protein, SUMO, which causes the mutant Htt to become more soluble and therefore more toxic to cells.
This looks to be a very important addition to the literature on Huntington's. The implication is that a drug which could prevent Rhes from SUMOylating mutant Htt would halt the progression of the disease (although it would presumably not reverse any damage which had already happened.) This is the kind of powerful explanation that neuroscientists who study psychiatric disorders dream about. Maybe in 50 years we will have a similar understanding of schizophrenia - maybe.

Huntington's is a fascinating disorder. The mechanism of inheritance is very distinctive - disease results when a certain section of DNA is too long, and the longer it is, the earlier and more severe the symptoms. And when the pathogenic region is too long, it tends to get even longer during the formation of sperm cells, so the children of fathers with Huntington's often suffer from a more severe, early-onset form. This phenemonon is called genetic anticipation and is unique to Huntingdon's and some similar disorders.

Huntington's is also one of the few disorders which can be accurately diagnosed genetically before the symptoms occur. Anyone at risk of the disease can take a DNA test and know their fate. Perhaps unsurprisingly, most choose not to.

ResearchBlogging.orgSubramaniam, S., Sixt, K., Barrow, R., & Snyder, S. (2009). Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity Science, 324 (5932), 1327-1330 DOI: 10.1126/science.1172871

I'm Louvre-ing It!

As of today, there are more that 35,000 paintings and art objects in the collection of Musée du Louvre. If I were to look at each and everyone of it, I probably would need to eat and sleep inside the museum for three months!

However, I had only an afternoon to spare for this museum and I had to be selective of what I wanted to see.




First on my list was La Jaconde, which was definitely unmistakable. Anybody who visited Musée du Louvre without seeing it is as good as not have been there. People who have not been to Musée du Louvre may not know who La Jaconde is, but everybody knows Mona Lisa!




Although my plan was to head straight to meet Mona Lisa, I got very distracted along the way with many more extraordinary artworks, those on the ceiling included.




I have forgotten the name of the artists of these paintings but they are no less popular than Da Vinci, Michelangelo, Donatello and Raphael. I think the following painting is by Botticelli if I have not mistaken.




I really can't recall the artist of the following painting, but I think it has great influence on the Japanese comics characters. Do you think that it is by Titian?




I have absolutely no idea of the person(s) who painted the following two paintings, but they are really stunning.






After passing through a few rooms, I finally arrived at Room 6 where Mona Lisa kept the tourists busy. There was a crowd around the big panel with a small-size painting. I had to slowly move in the queue to come face-to-face with La Jaconde. To be honest, I was quite disappointed with the size. Size does matter! With all the legends revolving around Mona Lisa, I was expecting at least a life-size painting. Beside the size, the art work is no doubt exemplary, but just one of the masterpieces amongst many by Leonardo Da Vinci.




Don't you think that the following painting is as stunning as Mona Lisa? It's not the artwork of Leonardo Da Vinci by the way.




Other than the paintings, Musée du Louvre has a vast collection of sculptures. One of the more popular ones is this literally armless Winged Victory of Samothrace from the Hellenistic period. It is places at the end of the Daru staircase.




The crown of one of the kings of France is also on display in a showcase. The inner part looks like a coconut shell.




As I walked along, I saw this interesting life-size marble sculpture which is very athletic. It is the Borghese Gladiator from the Hellenistic period.




Another sculpture not to be missed is The Dying Slave by Michelangelo.




There is another literally armless sculpture from the Hellenistic period which is one of the highlights in Musée du Louvre. She is Aphrodite, the goddess of the sea. This sculpture is named Venus de Milo as it was found on the island of Melos in Greece. I am craving for a glass of Milo with fresh milk while I am writing this.




At the Ancient Egypt Department, the Seated Scribe is probably the most precious of all the artifacts, despite its size. I can't forget the smile on the face of this figurine as it was gazing at me so gracefully.




It was the Mesopotamian Code of Hammurabi that concluded my tour of Musée du Louvre in one afternoon. I wanted to explore further but the museum guards needed to go home to have romance with their wives and husbands.


Rabu, 22 Juli 2009

The Anime Sensation, Aka The Japanese Invasion

The Anime Sensation has been around for many years. But it is only in recent years it has become so prevalent in American society. For literally decades Anime, otherwise known as Japanese animation has been becoming more mainstream for decades. The first one that most people remember tend to come from a small list of two. They either remember Star Blazers (aka SpaceCruiser Yamamoto) or they remember Akira, an anime movie that was ground breaking in many ways. There are also a few who first were introduced to Anime by Robotech. Robotech was much like Star Blazers in the fact that it was a large re-write of the stories from the original Japanese based stories. At the time of those releases, it was thought that a direct conversion of the stories would not hold the attention of American audiences. While it is debatable if that is a true supposition or not, the fact remains that Robotech, Star Blazers, and Akira were and are profitable franchises in the Anime field.

Now, in the 21st century there are many variations of Anime that have reached the American Shores. Once we invaded Japanese territory with weapons of personal destruction, now the Japanese have invaded our shores, with entertaining Anime. There are so many titles and types it defies easy listing. There are the types that first invaded, that are very much like Robotech. There is X-rated Anime, some that are so bad, such as the Legend of the Overlord, that any child viewing them could easily be scarred for life. Although adults may find such "tentacle love" as found and Overfiend entertaining and even exciting, it is most decidedly not for children.

Amime will show your common entertainment seeking American a different type of entertainment in the sort of creative animation that is very much beyond that of non-Japanese created animation. It is not to say that there are not some creative things to come from American studios, it is to say that the Japanese have been doing it longer, and in this authors opinion, better.

So the next time you are looking for something new to see, check out a little Anime. It wont hurt. And if you can not decide which one, we have two suggestions. Legend of the Overfiend which is very much an adult thing, or Akira, but this is close to the adult only, save that Akira is all violence and the Legend, well that is sex and violence. Some might call Legend straight up disgusting, but that is for you to decide for yourself I would think.

Otaku Nation: Anime's Effect on American Pop Culture

The modern age of Anime arrive in Japan in the 1960s, and over the course of the next decade or so boomed into the giant robot, space battle genre bender that we would soon recognize as the anime of today.

Evolving over the next 30 years or so, it reached a peak where it could begin to overtake and become an integral part of other cultures, much like the Hollywood of the 1930s quickly grew to encompass the rest of the world and inform their pop culture. In the same manner, American pop culture becomes increasingly informed by the trends and cult response to anime.

Anime first appeared in the US market in the 60s with shows like Kimba the White Lion and Astroboy. However, the national consciousness as to where these shows came from as well as the poor marketing of the shows made them forgettable and rather than a jumping in point, they act as a nostalgic reminder.

When Speed Racer arrived, the beginnings of a true consciousness that Japan was creating something new and exciting began to set in. The popularity of Speed Racer was never that of its American contemporaries, but it created in a set fanbase the willingness to devour newer offerings later on in Starblazers and Robotech (a convoluted perversion of multiple animes, but still a relative success in the states). Still, the affect was mostly underground.

In the 1980s, the introduction of Beta and VHS made it possible to join together with friends and watch more varying forms of anime. Truly it was the technological revolutions of the coming years that would make it truly possible for anime to perforate the American entertainment bubble. When Akira arrived in 1989, the effect was palpable. Receiving only a limited American screen release, few saw it in initial release, but the copying of VHS tapes and word of mouth made it something of a cult sensation. Those that knew of Akira were fans for life, eagerly awaiting their chance to partake more and more of the growing trends out of Japan.

For Japan’s part, this era was a period of major expansion, a veritable boom in the business. The 1980s saw the success of shows like Gundam and Dragon Ball overgrow the national consciousness and become runaway sensations. The explosion of the manga industry before hand, with serializations of works by Akira Toriyama and Katsuhiro Otomo in the early 80s simmered in the youth of Japan and finally seeing the commercial possibilities of these works, creating in the process a major conglomerate of companies in the Akira Committee to bring the massive budget of Akira to fruition.

By the 90s anime was the mainstream in Japan, and the result was the ramping up of production and increased output of shows. In part because of the simple, streamlined art style, multiple artist were able to work on a single project and create on episode a week for years at a time, resulting in monumental runs such as the case of Dragonball (156 episodes) and Dragonball Z (276 episodes). The ability to serialize and turn a story into something that millions of youths would tune into each and every week made companies billions (of yen) and secured the kinds of commercial sponsorships and funding necessary to undertake incredible projects that would require vast sums of money to complete.

Back in America, a few executives were beginning to see the effect these shows were having in Japan. Slowly and very carefully they began taking the most popular, Dragonball Z and Sailormoon for example and finding timeslots very early in the day, before the daily retinue of American cartoons, testing the waters of marketability. In 1995, the trickle of anime into the states was just that, a relative trickle. Sailormoon aired every morning in syndication, but chopped up and missing key seasons to relate the endings of important storylines. Dragonball Z ran an equally mild run early on Saturdays in syndication that was abruptly cut when the rights to the show were lost by the initial company and purchased by Funimation.

All the while, works from Japanese masters like Hayao Miyazaki were being overlooked, passing unnoticed through limited release in the states, while making him a God of his craft in Japan. All the while companies like Manga, Funimation, and Viz were buying up licenses and releasing little known, untraceable shows that no one knew the origin of. The shows were treated poorly, often dubbed and cut up to match American audiences. Viz even launched the first Anime magazine in 1993 with Animerica, primarily reviewing their own products but still giving a view of the culture that no one knew anything about.

But, in 1995, the release of the shows in America along with the premiere and rave reviews of Neon Genesis Evangelion in Japan, Otaku interest abroad began to spike. Otaku is a bid of a misnomer as it’s a bit of an insult in Japan, a mean spirited way to call someone a nerd. Here though, it generally means a purveyor of Japanese pop-culture and with the Otaku so in style right now it’s less of an insult than a clique. The import and fan subbing of shows began in earnest via VHS editing software that few if anyone had access to. The early 90s was a time of massive growth of interest in the little known import of Anime though, and the American marketplace wasn’t slow to react.

In 1997, television networks made broad sweeping moves to bring shows to the mainstream. The Sci-Fi channel had always had a small niche in its latenight line up for cult classics like Vampire Hunter D, but Warner Bros finally brought the genre to primetime. Funimation finally got their licensing figured out and Dragonball Z saw its triumphant return to the Cartoon Network, with new episodes to follow a year and a half later. And in 1998, a little known video game for the Gameboy exploded in the American market, bringing along with it its entire arsenal of marketing ploys, including the overwhelmingly childish, but enormously popular Pokemon anime. Finally, children across the nation were gluing themselves to the television set as earnestly as their Japanese counterparts had for nearly a decade before hand.

Miyazaki’s new film played to better reception, receiving a proper release via Miramax. Princess Mononoke was a success in the terms of the time, even receiving the coveted two thumbs up (let alone a review at all) from Siskel and Ebert. Films began to arrive in America more liberally, still finding limited release, but release at least. And the shows began to pour in. At the time, the fansub scene was more or less the only way to get access to some of the more obscure titles being released in Japan. But as the market boomed, so did the licensing by major companies, and it actually started to become illegal to fansub certain shows because they might be released by a company eventually.

Thus began the final and full assimilation of Japanese pop culture into American. The DVD format sped up the process, as more episodes of a show could be packed into a disc than a VHS and production costs plummeted, removing a lot of the financial risk of an untested foreign product in the American marketplace. Cartoon Network debuted its Toonami afternoon cartoon slot, in which they featured anime that had been around for a little while, but managed to appeal to a much larger demographic and spread the word about these great story driven cartoons from across the ocean. An entire generation grew into the growing popularity and became entranced by the epic storylines, amazing storytelling and ability to show in a cartoon what many considered adult themes and much more mature perspectives on things like competition and personal success. The Japanese ability to cross genre and the extremely high production values that started to go into shows made in the late 90s and beyond meant amazing shows that appealed not just to children but to adults and beyond.

What started as a crossover, slowly began to actually change the way in which American’s marketed their television to children. Shows with more adult content appeared, and in some cases emulated the Japanese format. The writers at Pixar crafted brilliant, more maturely themed cartoons without the silly musicals of Disney past, and Disney even dissolved their tried format in favor of more mature, complete stories. The devolution of American quality in cartoons though as they attempted to match the output meant even more Japanese entries in the market. Now, if you turn on Fox kids in the morning you’ll find over half of the shows on are animes. And Cartoon Network still presents multiple entries themselves, with more mature offerings in their Adult Swim block late at night. Spirited Away won the Oscar for best animation in 2003 and South Park, the quintessential American barometer of cultural trends at first knocked the trend with their Chinpokemon episode, later to embrace it (while still mocking it) via changing their own art style in the Weapons episode just a couple years ago.

Nowadays, you’ll find anime oriented t-shirts everywhere, an entire aisle devoted to DVD releases in Best Buy (compared to the one row only seven years ago) and the success of the Anime Network, a channel solely devoted to Anime programming. Magazines like Newtype, a Japanese trade magazine for the Anime industry is now translated and released in America every month with previews of new shows, and American directors like James Cameron are looking to direct live action versions of manga like Battle Angel Alita.

Now, we see new releases from Japan within six months, and the fansub community has to scramble to keep up with what’s legal and what’s not legal to offer via their online services. The internet itself has made it a huge community, where a show can be recorded on Japanese television, ripped and subbed, then uploaded within a couple hours for the world to view. There’s no lay over, and new shows are immediately available. And it’s evident in the universities too. Japanese is one of the most sought after languages, filling up immediately with a yard long waiting list every year, and more sections being added every year.

Japanese pop culture managed to tap a certain perspective that American counterparts were unable to do themselves and in so doing, cornered and grew in a market that few thought existed in America.

Selasa, 21 Juli 2009

Sherlock Holmes

"In teaching the treatment of disease and accident, all careful teachers have first to show the student how to recognise accurately the case. The recognition depends in great measure on the accurate and rapid appreciation of small points in which the diseased differs from the healthy state. In fact, the student must be taught to observe. To interest him in this kind of work we teachers find it useful to show the student how much a trained use of the observation can discover in ordinary matters, such as the previous history, nationality, and occupation of a patient."

The above quote is by Dr Joseph Bell (1837-1911), who was a professor of clinical surgery at Edinburh University. He came from a distingushed medical family. His great grandfather being Benjamin Bell, also a noted forensic surgeon. Another relative was Charles Bell, who described (and had named after him) the condition known as Bells' Palsey. Whenever Queen Victoria was in Scotland, Bell was her personal surgeon, and later was honorary surgeon to Edward VII. He was well known and respected before Arthur Conan Doyle met him, having published a number of medical textbooks, and prolific journal articles, and for 23 years he was editor of the Edinburgh Medical Journal.

He was a popular lecturer at the university, his lectures invariably attended to capacity. It was whist studying medicine at Edinburgh in 1877 that Arthur Conan Doyle first met Bell, and was immediately impressed. Doyle proved to be a first rate student, and Bell in turn was equally complimentary, writing of Doyle "Dr. Conan Doyle's education as a student of medicine taught him how to observe, and his practice has been a splendid training for a man such as he is, gifted with eyes, memory, and imagination. Eyes and ears which can see and hear, memory to record at once and recall at pleasure the impressions of the senses, and imagination capable of weaving a theory or piecing together a broken chain or unravelling a tangled clue. Such are the implements of his trade to a successful diagnostician." He went on to add that Doyle's gift as a natural story teller in combination with these attributes only made it a matter of choice as to wether he wrote detective stories, or saved his strength for a great historical romance.

By the end of Conan Doyle's second year at the University Bell selected him to be his clerk and assistant at the Royal Infirmary's open clinic. In this position Conan Doyle often heard Bell make "amazing" deductions whilst leading students on his rounds. On one occasion he witnessed Bell telling students that a new patient was a recently discharged non-commisioned officer who had been serving in a Highland regiment stationed in Barbados. Going on to explain "You see gentlemen, the man was a respectful man but did not remove his hat. They do not in the army, but he would have learned civilian ways had he been long discharged. He has an air of authority and is obviously Scottish. As to Barbados, his complaint is elephantiasis, which is West Indian, and not British."

On another occasion, also witnessed by Doyle, a mans address, combined with the callused ball of his thumb indicated to Bell that the man was a sailmaker. The reasoning being that he lived on a street near the docks, and sail makers typically have calloused thumbs from stitching the heavy canvas sails.

Many other incidents of similar nature were witnessed by Doyle and were often used in Sherlock Holmes stories later. In A Study In Scarlet, Holmes explains to Watson why he concludes that a man had recently been in Afghanistan. "Here is a gentleman of a medical type, but with the air of a military man. Clearly an army doctor then. He has just come from the tropics, for his face is dark, and that is not the natural tint of his skin, for his wrists are fair. He has undergone hardship and sickness as his haggard face says clearly. His left arm has been injured. He holds it in a stiff an unnatural manner. Where in the tropics could an English army doctor have seen much hardship and got his arm wounded? Clearly in Afghanistan."

It is obvious that Conan Doyle was much influenced by the charismatic Bell, and based his famous detective Sherlock Holmes largely upon him. Although the character first created by Edgar Allan Poe in "The Murders In The Rue Morgue", that is Auguste C. Dupin, undoubtedly also was incorporated into the persona, It is my (and that of others far more knowledgable than I) opinion that Dr. Joseph Bell was in fact the real Sherlock Holmes.

Detective Conan


Detektif Conan (bahasa Jepang: 名探偵コナン Meitantei Konan) adalah sebuah manga dan anime detektif karangan Gosho Aoyama. Detektif Conan diterbitkan dalam majalah Weekly Shōnen Sunday. Selain dalam format manga dan anime, Detektif Conan juga telah dibuat dalam bentuk film dan drama TV.

Detektif Conan menceritakan tentang Shinichi Kudo, seorang detektif SMA, yang tubuhnya mengecil akibat obat yang diberikan oleh sebuah organisasi misterius tanpa diketahui organisasi tersebut. Supaya identitas aslinya tidak diketahui organisasi tersebut, Shinichi menyamar sebagai Conan Edogawa, dan tinggal di kantor Detektif Kogoro Mouri. Conan Edogawa telah banyak membantu Kogoro memecahkan kasus, sehingga Kogoro menjadi detektif terkenal.

Shinichi Kudo, detektif SMA yang memiliki kemampuan luar biasa dalam menganalisa kasus-kasus kriminal terkena suatu masalah besar ketika tiba-tiba dirinya menjadi mengecil setelah diberi minum obat misterius, yang kemudian diketahui adalah racun berkode APTX 4869, oleh 2 anggota Organisasi Hitam yaitu Gin dan Vodka. Saat kejadian itu Shinichi dan Ran Mouri sedang berkencan di sebuah taman tema (theme park) yang bernama "Tropical Land". Kemudian, Shinichi bertemu dengan dua orang yang mencurigakan, dan Shinichi pun membuntuti mereka. Karena keasyikan mengintip transaksi gelap yang dilakukan Vodka dengan seorang usahawan, tanpa sadar Shinichi dipukul oleh Gin, dan dicekoki obat misterius yang dimaksud untuk membunuh Shinichi.

Namun ternyata obat tersebut tidak membunuh Shinichi, melainkan terjadi efek samping dari obat tersebut yang mengakibatkan tubuhnya mengecil seperti bocah berusia tujuh tahun.

Kemudian atas saran dari Profesor Agasa, Shinichi mengganti namanya menjadi Conan Edogawa. Nama "Conan" berasal dari nama pengarang buku detektif terkenal Sherlock Holmes, Sir Arthur Conan Doyle, sedangkan nama "Edogawa" berasal dari nama Edogawa Ranpo. Conan lalu mulai mencari tahu seluk beluk organisasi misterius tersebut, sambil tinggal di rumah teman sejak kecilnya, Ran Mouri, yang tidak mengetahui identitas asli Conan.

Karena mengecilnya tubuh Shinichi, pada mulanya analisis Conan sama sekali tidak dipercaya karena dianggap sebagai anak kecil. Jadi, Conan terpaksa membuat ayah Ran, Kogoro Mouri, yang merupakan seorang detektif payah, untuk memecahkan berbagai kasus kejahatan, dengan harapan dapat melacak jejak organisasi tersebut. Kemudian kisah selanjutnya menjadi semakin rumit dan melibatkan berbagai individu.

Anggota Organisasi Hitam yang telah diketahui adalah Gin, Vodka, Vermouth, Pisco, Tequilla, Calvados, Chianti, Keel, Coroon, Sherry serta big boss yang selalu ditampilkan secara blur/kabur.

Senin, 20 Juli 2009

Ben 10 Alien Force


Ben 10 Alien Force, a sequel to Ben 10, is a marvelous and an interesting anime Television series, which is the result of hard work done by Dwayne McDuffie and Glen Murakami and the studio "Man of Action". The studio is a group of 4 young creative personalities named, Duncan Rouleau, Joe Casey, Joe Kelly, and Steven T. Seagle. Ben 10 Alien Force is produced by Cartoon Network Studios, and is based on the central figure Ben Tennyson. He is now 15 years of age and has grown up to become a more matured guy with a clear outlook towards life. He has removed the Omnitix, and has tasted the good and challenging adventures out there.

Now, in Ben 10 Alien Force, you see there is a fanatic aliens known as Highbreed have surreptitiously com on Earth and they have the mission to ruin the earth and kill its inhabitants altogether. Max, who is Ben's grandfather and also an active member of the planet-defending Plumbers has already gone out there to protect the humanity from their evil deeds, but nobody has heard of him ever since. There stands no choice in front of Ben, but to use Omnitrix to fight the aliens back from the earth. Omnitrix has adapted according to his teenage body, and this has resulted into new forms and functions, and makes Ben ready to go for fighting the aliens.

Ben is supported in his endeavor by Cousin Gwen, and both have their natural abilities enhanced to give the Highbreed a tough blow. Ben's formal rival, Kevin Levin who worked in Null Void is also coming in front and joining his hand.

The cartoon animated series has all its drama and adventure lined up for the children and the adults. What's more, the animated series has got all the super digital sound and backed by orphic music scores. The best thing is that you don't get bored while watching the entire series. Ben is leading the fight the war against the aliens and also on his mission to look for Max. In the time of five years that has past, been has become more matured and he has all the goals set in line to go ahead with the mission along with his cronies. Come and explore the adventure filled mission where the fight for the cause is truly realized by the saviors who are packed with their guns.